免费三级现频在线观看播放-欧美激情视频一区二区三区不卡-国产国语?v毛片在线看-亚洲精品免费视频-99热精品免费观看-91免费永久国产在线观看的在线直播平台-国产成人综合亚洲欧在线-免费日韩影视剧在线平台

Precocious puberty, a pediatric endocrine disorder classified as central precocious puberty (CPP) or peripheral precocious puberty (PPP), is influenced by diet, gut microbiota, and metabolites, but the specific mechanisms remain unclear. Our study found that increased alpha -diversity and abundance of short -chain fatty acid-producing bacteria led to elevated levels of luteinizing hormone and follicle -stimulating hormone, contributing to precocious puberty. The integration of specific microbiota and metabolites has potential diagnostic value for precocious puberty. The Prevotella genus -controlled interaction factor, influenced by complex carbohydrate consumption, mediated a reduction in estradiol levels. Interactions between obesity -related bacteria and metabolites mediated the beneficial effect of seafood in reducing luteinizing hormone levels, reducing the risk of obesity -induced precocious puberty, and preventing progression from PPP to CPP. This study provides valuable insights into the complex interplay between diet, gut microbiota and metabolites in the onset, development and clinical classification of precocious puberty and warrants further investigation.