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人才隊(duì)伍

全體研究組長

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邱菊

博士

炎癥與免疫調(diào)節(jié)研究組組長

郵箱: qiuju@sinh.ac.cn

電話: +86-21-54923301

所屬部門: 腫瘤與微環(huán)境重點(diǎn)實(shí)驗(yàn)室

個(gè)人簡歷

2017-至　今：中國科學(xué)院上海營養(yǎng)與健康研究所研究員
2014-2016年：中國科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所研究員
2009-2014年：西北大學(xué)Feinberg醫(yī)學(xué)院微生物與免疫學(xué)系博士后
2009.04-2009.11：愛因斯坦醫(yī)學(xué)院細(xì)胞生物學(xué)系博士后
2004-2009年：上海交通大學(xué)醫(yī)學(xué)院免疫學(xué) 醫(yī)學(xué)博士
1999-2004年：泰山醫(yī)學(xué)院（現(xiàn)山東第一醫(yī)科大學(xué)）臨床醫(yī)學(xué) 學(xué)士

研究方向

固有淋巴樣細(xì)胞與黏膜免疫

研究內(nèi)容

固有淋巴樣細(xì)胞（Innate lymphoid cells, ILC）是一群譜系陰性（Lin-）、缺乏T、B細(xì)胞抗原特異性受體的固有免疫細(xì)胞亞群。ILC廣泛存在于多種器官及黏膜組織，在感染性疾病、過敏性疾病、自身免疫病及腫瘤中發(fā)揮重要作用。我們利用炎癥性疾病動(dòng)物模型、基因工程小鼠和分子生物學(xué)等手段，主要研究調(diào)控ILC2和ILC3發(fā)育、分化和功能的分子機(jī)制，解析ILC與微環(huán)境互作的機(jī)制和對疾病的影響機(jī)制，從而為診斷或治療炎癥性疾病提供理論依據(jù)和新手段。

代表論著（#第一作者，*通訊作者）

Jupei Tang^#, Hanxiao Sun^#, Huidan Chang, Liyun Yuan, Yue Chen, Xueliang Zhang, Yongzhen Tao, Lifeng Yang, Zhen Shao, Xiaohuan Guo, Hong Zhou, Huiming Sheng, Qiang Zou, Xiao Su, Jinxin Qiu*, Jun Qin*, Ju Qiu*. Brg1-imprinted chromatin status controls the effector and memory ILC2 metabolism to exacerbate allergic lung inflammation. J Allergy Clin Immunol 2025 Sep 17:S0091-6749(25)00948-0. doi: 10.1016/j.jaci.2025.08.029
Hanxiao Sun, Jinxin Qiu*, Ju Qiu*. Epigenetic regulation of innate lymphoid cells. Eur J Immunol 2024 Sep;54(9):e2350379 (invited review)
Hanxiao Sun, Jie Shu, Jupei Tang, Yue Li, Jinxin Qiu, Zhaoyun Ding, Binbin Xuan, Minghui Chen, Chenxin Gan, Jinpiao Lin, Ju Qiu*, Huiming Sheng*, Chuanxin Wang*. GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells. Immunology 2024 Jul;172(3):451-468
Zhaoyun Ding^#, Ting Cai^#, Jupei Tang, Hanxiao Sun, Xinyi Qi, Yunpeng Zhang, Yan Ji, Liyun Yuan, Huidan Chang, Yanhui Ma, Hong Zhou, Li Li*, Huiming Sheng*, Ju Qiu*. Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation. Nat Commun 2022 Dec 3;13(1):7468
Zhao Li^#, Hanxiao Sun^#, Zhitao Gu*, Ju Qiu*. Emerging roles of ILC2s in antitumor immunity. Cell Mol Immunol 2022 Nov;19(11):1311-1313
Jinxin Qiu, Yanhui Ma*, Ju Qiu*. Regulation of intestinal immunity by dietary fatty acids. Mucosal Immunol 2022 May;15(5):846-856
Jiali Chang, Xiaojuan Ji, Tian Deng, Jinxin Qiu, Zhaoyun Ding, Zhao Li, Yanhui Ma, Xiaoyu Hu, Li Li*, Ju Qiu*. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. Cell Rep 2022 Mar 15;38(11):110530
Jingjing Zhang^#, Jinxin Qiu^#, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He*, Ju Qiu*, Lei Shen*. Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity. Nat Immunol 2022 Feb;23(2):237-250
Qiu J^#, Zhang J^#, Ji Y*, Sun H^#, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H*, Shen L*, Qiu J*. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol 2021 Nov;14(6):1306-1322
Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 2021 Jan;14(1):38-52
Deng T, Suo C, Chang J, Yang R, Li J, Cai T, Qiu J*. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol Immunol 2020 Feb;17(2):163-177
Li J^#, Shi W^#, Sun H, Ji Y, Chen Y, Guo X, Sheng H, Shu J, Zhou L, Cai T, Qiu J*. Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. Nat Commun 2019 Jul 29;10(1):3371
Ting Cai^#, Jinxin Qiu^#, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng*, Lei Shen*, Ju Qiu*. IL-17-producing-ST2+ILC2 plays a pathogenic role in lung inflammation. J Allergy Clin Immunol 2019 Jan;143(1):229-244
Ye J^#, Qiu J^#, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep 2017 Nov 21;21(8):2277-2290
Suo C, Fan Z, Zhou L, Qiu J*. Perfluorooctane sulfonate affects intestinal immunity against bacterial infection. Sci Rep 2017 Jul 12;7(1):5166
Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu*, Yonghui Wang*. Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. Med Chem Commun 2016;7(12):2344-2348
Qiu J, Zhou L. Aryl hydrocarbon receptor promotes RORγt(+) group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol 2013 Nov;35(6):657-670
Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, Fu YX, Zhou L. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013 Aug 22;39(2):386-399
Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2012 Jan 27;36(1):92-104

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人才隊(duì)伍

邱菊

個(gè)人簡歷

研究方向

研究內(nèi)容

代表論著（#第一作者，*通訊作者）

代表論著（#第一作者，*通訊作者）