郵箱: weijunpan@sinh.ac.cn
電話: +86-21-54923309
所屬部門: 營養(yǎng)代謝與食品安全重點實驗室
2017-至 今：中國科學院上海營養(yǎng)與健康研究所 研究員
2012-2016年：中國科學院上海生命科學研究院/上海交通大學醫(yī)學院健康科學研究所 研究員
2009-2012年：美國國立衛(wèi)生研究院 兒童健康與人類發(fā)育研究所 博士后
2005-2009年：美國耶魯大學，醫(yī)學院藥學系 博士后
1999-2005年：中國科學院上海生命科學研究院生化與細胞所 理學博士 導師：李林 研究員
1995-1999年：華東理工大學 生物工程學院 生物化學系 理學學士
造血-循環(huán)系統(tǒng)的發(fā)育與穩(wěn)態(tài)
主要從事造血-循環(huán)系統(tǒng)發(fā)育與穩(wěn)態(tài)調(diào)控的信號轉(zhuǎn)導機理研究。通過整合遺傳篩選、遺傳定位和活體成像、單細胞分析、生化分析和小分子化合物大規(guī)模篩選等研究手段，探索微環(huán)境信號網(wǎng)絡調(diào)控中胚層組織器官共發(fā)育、穩(wěn)態(tài)維持及相關(guān)疾病過程的分子機制。近期重點研究：（1）血管與造血干細胞協(xié)同發(fā)育；（2）血管網(wǎng)絡形成及穩(wěn)態(tài)調(diào)控；（3）造血干細胞歸巢及增殖分化的分子細胞調(diào)控基礎，聚焦若干跨膜蛋白質(zhì)分子、酯/脂質(zhì)分子及膜動態(tài)平衡為核心的信號轉(zhuǎn)導機制研究，積極推進相關(guān)人類疾病致病機理及臨床轉(zhuǎn)化應用研究。
1.?Shuang Wu#, Kai Chen#, Tao Xu#, Ke Ma, Lei Gao, Cong Fu, Wenjuan Zhang, Changbin Jing, Chunguang Ren, Min Deng, Yi Chen, Yi Zhou, Weijun Pan*, Xiaoe Jia*. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Front Cell Dev Biol 2021 Oct 13;9:709923.
2.?Xiaofen Liu, Wenjuan Zhang, Changbin Jing, Lei Gao, Cong Fu, Chunguang Ren, Yimei Hao, Mengye Cao, Ke Ma*, Weijun Pan*, Dantong Li*. Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis. Front Cell Dev Biol 2021 Apr 30;9:670654.
3.?Lantian Wang#, Jing Fan#, Lili Han#, Haonan Qi#, Yimin Wang, Hongye Wang, Suli Chen, Lei Du, Sheng Li, Yunbin Zhang, Wei Tang, Gaoxiang Ge, Weijun Pan*, Ping Hu*, Hong Cheng*. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis 2020 May 11;11(5):357.
4.?Wencao Zhao#, Le Cao#, Hanru Ying#, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Mengye Cao, Cong Fu, Haonan Qi, Yimei Hao, Yun-Chi Tang, Jun Qin, Tao P Zhong, Xiaoxi Lin, Luyang Yu, Xuri Li, Lin Li, Dianqing Wu, Weijun Pan*. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res 2019 Nov;29(11):895-910.
5.?Dantong Li#, Wenzhi Xue#, Mei Li#, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O. Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu，Weijun Pan*. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature 2018 Dec;564(7734):119-124.
6.?Xiaoli He#, Wenjuan Zhang#, Chen Yan#, Fen Nie, Chen Li, Xiaofen Liu, Cong Fei, Shengdi Li, Xiaomin Song, Yingying Jia, Rong Zeng, Dianqing Wu, Weijun Pan*, Xiaojiang Hao*, Lin Li*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov 2017 Jan 31;3:1700.
7.?Xiao-E Jia#, Tao Xu#, Ke Ma#, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I. Zon, Yi Zhou*, Saijuan Chen*, Weijun Pan*. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res 2015 Aug;25(8):946-962.
8.?Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiaoe Jia, Shuang Wu, XinSun, Mei Dong, Min Deng, Yi Chen, Wenge Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon, Weijun Pan*. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet 2015 Jul 1;11(7):e1005346.
9.?Ingyu Kim#, Weijun Pan#*, Sara A. Jones, Youxin Zhang, Xiaowei Zhuang, Dianqing Wu*. Clathrin and AP2 are required for PtdIns(4,5)P-2-mediated formation of LRP6 signalosomes. J Cell Biol 2013 Feb 18;200(4):419-428.
10.?Weijun Pan#, Van N. Pham#, Amber N. Stratman, Daniel Castranova, Makoto Kamei, Kameha R. Kidd, Brigid D. Lo, Kenna M. Shaw, Jesus Torres-Vazquez, Constantinos M. Mikelis, Silvio J. Gutkind, George E. Davis, Brant M. Weinstein. CDP-diacylglycerolsynthetase-controlled phosphoinositide availability limitsVEGFA signaling and vascular morphogenesis. Blood 2012 Jul 12;120(2):489-498.
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