郵箱: zhangls@sinh.ac.cn
電話: +86-21-
所屬部門(mén): 腫瘤與微環(huán)境重點(diǎn)實(shí)驗(yàn)室
2026.08－至 ???今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2021.08－2026.07：中國(guó)科學(xué)院腦科學(xué)與智能技術(shù)卓越創(chuàng)新中心 博士后
2018.05－2020.04：芝加哥大學(xué)生物科學(xué)部?博士聯(lián)合培養(yǎng)
2014.09－2021.06：中國(guó)科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心?博士
2010.09－2014.06：山東大學(xué)生命科學(xué)學(xué)院?學(xué)士
基因體內(nèi)功能的高通量解析及衰老與衰老相關(guān)疾病的干預(yù)研究
運(yùn)用高通量體內(nèi)擾動(dòng)測(cè)序（Perturb-seq）和單細(xì)胞多組學(xué)等前沿技術(shù)，系統(tǒng)解析基因在生理和病理狀態(tài)下的體內(nèi)功能，篩選衰老與衰老相關(guān)疾?。ㄈ缟窠?jīng)退行性疾病、代謝性疾病等）的新型治療靶點(diǎn)，并在此基礎(chǔ)上開(kāi)發(fā)相應(yīng)的靶向干預(yù)策略。研究方向包括：（1）體內(nèi)Perturb-seq系統(tǒng)的優(yōu)化和升級(jí)；（2）基因在體內(nèi)生理和病理?xiàng)l件下的功能圖譜繪制；（3）衰老與衰老相關(guān)疾病新型治療靶點(diǎn)的高通量篩選及靶向干預(yù)策略的開(kāi)發(fā)。
1. Liansheng Zhang#, Qi Ma#, Xiangrui Kong#, Weijuan Zou#, Bo Wang#, Bin Wu#, Shicheng Cai, Tao Bai, Runlin Tan, Ziji Dai, Xingyu Liu, Zhiheng Jia, Meimei Zhang, Tianwen Li, Yuanyi Zheng*, Xinde Hu*, Jianrong Wu*, Zhengzheng Xu*, Haibo Zhou*. Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq. Science. 2026;392(6796):eadw2156. doi:10.1126/science.adw2156
2. Liansheng Zhang#,*, Xiangrui Kong#, Qi Ma#, Xinde Hu#,*, Shicheng Cai#, Bo Wang#, Weijuan Zou, Tao Bai, Meimei Zhang, Liu Fan, Runlin Tan, Ziji Dai, Zhiheng Jia, Tianwen Li, Xingyu Liu, Huatai Xu, Jianrong Wu, Yuanyi Zheng, Zhengzheng Xu*, Haibo Zhou*. Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq. Nature Genetics. 2026. doi:10.1038/s41588-026-02638-3
3. Liansheng Zhang#,*, Zhengzheng Xu#, Zhiheng Jia#, Shicheng Cai#, Qiang Wu, Xingyu Liu, Xinde Hu, Tao Bai, Yongyu Chen, Tianwen Li, Zhen Liu, Bin Wu, Jianhong Zhu, Haibo Zhou*. Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration. Nature Aging. 2025;5(3):468-485. doi:10.1038/s43587-024-00792-z.
4. Tianwen Li#, Liansheng Zhang#, Peng Wang#, Jingyu Yu#, Junjie Zhong#, Qisheng Tang, Tongming Zhu, Kezhu Chen, Fengshi Li, Pengjie Hong, Jiachen Wei, Xicai Sun, Guangchao Ji, Bin Song*, Jianhong Zhu*. Extracellular vesicles from neural stem cells safeguard neurons in intracerebral hemorrhage by suppressing reactive astrocyte neurotoxicity. Cell Reports. 2024;43(10):114854. doi:10.1016/j.celrep.2024.114854.
5. Liansheng Zhang#, Zhiheng Jia#, Qiang Wu#, Tao Bai, Bo Wang, Xinde Hu, Tianwen Li, Xingyu Liu, Jiqiang Fu, Yuelei Chen, Xiaoyan Ding, Zhen Liu, Zhengzheng Xu*, Haibo Zhou*. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice. Nature Metabolism. 2023;5(10):1787-1802. doi:10.1038/s42255-023-00887-8.
6. Tianwen Li#, Liansheng Zhang#, Tao Lu#, Tongming Zhu#, Canbin Feng, Ni Gao, Fei Liu, Jingyu Yu, Kezhu Chen, Junjie Zhong, Qisheng Tang, Quan Zhang, Xiangyang Deng, Junwei Ren, Jun Zeng, Haibo Zhou*, Jianhong Zhu*. Engineered extracellular vesicle-delivered CRISPR/CasRx as a novel RNA editing tool. Advanced Science. 2023;10(10):e2206517. doi:10.1002/advs.202206517.
7. Liansheng Zhang#,*, Jie Li#, Anning Lin*. Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice. STAR Protocols. 2021;2(4):100915. doi:10.1016/j.xpro.2021.100915.
8. Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S Sisodia, Yong-Hui Jiang, Xiaohua Cao, Naihe Jing*, Anning Lin*. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience, 2021;24(9):102942. doi:10.1016/j.isci.2021.102942.
9.?Jie Li#, Liansheng Zhang#, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang, Anning Lin*. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. eLife. 2020;9:e56309. doi:10.7554/eLife.56309.
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